Metaxalone: MedlinePlus Drug Information (2024)

pronounced as (me tax' a lone)

  • Why is this medication prescribed?
  • How should this medicine be used?
  • Other uses for this medicine
  • What special precautions should I follow?
  • What should I do if I forget a dose?
  • What side effects can this medication cause?
  • What should I know about storage and disposal of this medication?
  • In case of emergency/overdose
  • What other information should I know?
  • Brand names

Why is this medication prescribed?

Metaxalone, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

How should this medicine be used?

Metaxalone comes as a tablet to take by mouth. It usually is taken three or four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metaxalone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

Before taking metaxalone,

  • tell your doctor and pharmacist if you are allergic to metaxalone, any other medications, or any of the ingredients in metaxalone tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking metaxolone. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had kidney disease, liver disease, seizures, or a blood disorder.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking metaxalone, call your doctor immediately.
  • talk to your doctor about the risks and benefits of taking metaxalone if you are 65 years of age or older. Older adults should not usually take metaxalone because it is not as safe or effective as other medications that can be used to treat the same condition.
  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how metaxalone affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Metaxalone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness
  • dizziness
  • headache
  • nervousness

If you experience any of the following symptoms, call your doctor immediately:

  • agitation, hallucinations, coma
  • fast heart rate, high body temperature
  • muscle twitching, loss of muscle control
  • nausea, vomiting, diarrhea
  • severe skin rash
  • difficulty breathing
  • yellowing of the skin or eyes
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • seizures

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medications. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Skelaxin®
Last Revised - 07/15/2022

Browse Drugs and Medicines

Metaxalone: MedlinePlus Drug Information (2024)

FAQs

Is metaxalone bad for you? ›

While it's thought to have fewer side effects than other muscle relaxers, metaxalone still has risks. Common metaxalone side effects include drowsiness, dizziness, and headache. Nausea and gastrointestinal upset may also occur. Serious side effects, such as serotonin syndrome, may need immediate medical attention.

Is metaxalone hard on the kidneys? ›

Metaxalone is metabolized by the liver and subsequently eliminated by the kidney, thus both parent drug and metabolites may accumulate in such patients. Therapy with metaxalone should be administered cautiously in patients with mild to moderate hepatic and/or renal impairment.

Is metaxalone hard on the liver? ›

METAXALONE (SKELAXIN)

Adverse effects are also similar, with the exception of drug-associated hemolytic anemia and impaired liver function. Hepatotoxicity associated with metaxalone has not been as severe as that reported with chlorzoxazone. Monitoring of liver function is recommended with long-term use.

What should you not take with metaxalone? ›

This medicine may also interact with the following medications:
  • alcohol.
  • antihistamines for allergy, cough and cold.
  • certain medicines for anxiety or sleep.
  • certain medicines for depression like amitriptyline, fluoxetine, sertraline.
  • certain medicines for seizures like phenobarbital, primidone.

What is the safest muscle relaxer? ›

Metaxalone (Skelaxin) is a muscle relaxer that has the fewest reported side effects. It's also the least likely of the muscle relaxants to make you sleepy. It may work better for chronic lower back pain that is flaring up, rather than for pain that's new.

Is metaxalone being discontinued? ›

SKELAXIN (metaxalone) is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The 400-mg dosage strength is currently listed in the “Discontinued Drug Product List” section of the Orange Book.

Is metaxalone safe for elderly? ›

talk to your doctor about the risks and benefits of taking metaxalone if you are 65 years of age or older. Older adults should not usually take metaxalone because it is not as safe or effective as other medications that can be used to treat the same condition. you should know that this drug may make you drowsy.

Does metaxalone raise blood pressure? ›

Does metaxalone raise blood pressure? High blood pressure isn't a common side effect of metaxalone. If you notice that you have unusually high blood pressure after you take this medication, it could be a sign of a serious condition called serotonin syndrome.

Can you take metaxalone long-term? ›

If the drug is used for long-term treatment, it can cause hepatotoxicity and renal dysfunction.

What is a substitute for metaxalone? ›

Metaxalone Alternatives Compared
MetaxaloneCyclobenzaprineTizanidine
Dosage Forms Available
Oral tabletOral capsule, extended release Oral tabletOral capsule Oral tablet
Brand Names
Metaxall, SkelaxinAmrix, Comfort Pac with CyclobenzaprineZanaflex
39 more rows

Which is better, metaxalone or Flexeril? ›

Flexeril has an average rating of 6.1 out of 10 from a total of 233 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 27% reported a negative effect. Metaxalone has an average rating of 7.2 out of 10 from a total of 126 ratings on Drugs.com.

Is metaxalone an anti-inflammatory? ›

Metaxalone is a skeletal muscle relaxant. It is neither a non-steroidal anti-inflammatory drug (NSAID) nor an analgesic (painkiller).

Should I eat before taking metaxalone? ›

How to use Metaxalone. Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

What medications Cannot be taken with muscle relaxers? ›

You should not take muscle relaxants with:
  • alcohol.
  • CNS depressant drugs, such as opioids or psychotropics.
  • sleeping medications.
  • herbal supplements such as St. John's wort.

Is metaxalone good for nerve pain? ›

The exact way metaxalone works has not been established; however, experts suggest it suppresses brain activity which results in sedation, reducing the sensation of pain. It has no direct action on muscles, motor endplates, or nerve fibers and does not directly relax tense skeletal muscles.

Can you take metaxalone daily? ›

Metaxalone comes as a tablet to take by mouth. It usually is taken three or four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Can you take metaxalone long term? ›

If the drug is used for long-term treatment, it can cause hepatotoxicity and renal dysfunction.

Can muscle relaxers be bad for you? ›

Muscle relaxer misuse can lead to an increased risk of overdose, which can result in: Changes in consciousness. Hallucinations. Seizures.

Is Skelaxin a safe muscle relaxer? ›

You may need a dose adjustment or special tests to safely take Skelaxin. Skelaxin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol.

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